Two U.S. service members were killed in a strike on a base in Jordan overnight, according to U.S. Central Command.
A third service member is missing in action, CENTCOM said.
Four other U.S. service members were medically evacuated to hospital in Jordan, and have since been discharged. There were other service members treated for minor injuries, CENTCOM said.
The deaths were the 15th and 16th among U.S. service members in the current war with Iran. Six service members were killed in an Iranian attack on a base in Kuwait in March.
Also in March, six were killed when a refueling plane crashed in Iraq and one was killed in an Iranian strike on the Prince Sultan Air Base in Saudi Arabia.
In the most recent death, a U.S. Navy pilot died when his MH-60S helicopter made an emergency landing at sea last month.
The U.S. military said Friday it completed a seventh night of strikes against Iran, marking one week of nightly attacks on Iranian targets, as hostilities between the two countries ramp up again.
Iran’s Revolutionary Guards claimed a new series of strikes targeting U.S. military facilities across the Middle East on Friday, alleging attacks on sites in Syria, Kuwait, Oman, Bahrain and Jordan. The U.S. military denied those claims Friday.
This is just as Iran’s supreme leader Mojtaba Khamenei warned on Saturday of “unforgettable lessons” if US continued its attacks.
A new statement attributed to Khamenei, still unseen since the war began, was read out on state television.
He also called US President Donald Trump’s signature “worthless and invalid,” after an Iranian negotiator earlier Saturday said Tehran was suspending its commitments to the interim deal signed by both countries about a month ago.
The deal was aimed at permanently ending the war.
Khamenei said the US should know that the Iranian nation and the “resistance front” had “unforgettable lessons” for it.
Written from agency reports